The short answer is “it depends.” Most people correlate DUI conviction with alcohol. However, you can still be convicted of a DUI without having any alcohol in your system. Generally speaking, any sort of prescription medication that impairs and affects your driving could be the reason of a police officer stopping you. Typical prescription drugs that could lead to a DUI arrest are Xanax, certain antihistamines, sleep aids, and antidepressants. However, it is the burden of the State and the prosecutor to show that someone who takes prescription medicine is incapable of driving without being impaired.  If you are prescribed prescription medicine, consult with your doctor to determine if it would impair your driving and never take more than the prescribed dose.